The instructions I received at the time of my Reclast infusion said that ibuprofen was not recommended due to interaction with the Reclast. In the hospital the providers followed those instructions and I was offered just Tylenol or narcotics (which I don't want). Fnally after 5 days of severe pain I googled Reclast and WebMD recommended both ibuprofen and Tylenol for pain relief. Since I don't happen to respond to ibuprofen (there is individual variability as to which Non Steroidal Anti Inflammatory Drug (NSAID) you get relief from), I took naproxen and got immediate relief. However NSAIDs cause GI irritation, so I alternated Tylenol and naproxen and that reduced the pain. After a week my daughter suggested aspirin and I found that 1 tab 325 mg at bedtime prevented or markedly reduced the headaches that were waking me up early each morning after Reclast. I took aspirin each night for 3 nights until I developed the pulmonary emboli; then I had to start anticoagulant therapy (which has no effect on pain) and stop the aspirin.
Because of the double vision that I have also developed, I was started urgently on high dose prednisone while tests and consultations are being done to determine the cause; prednisone immediately stopped all headaches. But of course you wouldn't be prescribed steroids until it was absolutely necessary (they are testing whether I developed an auto-immune reaction to Reclast and a condition called giant cell arteritis which has a 15-20% risk of sudden permanent blindness).