Hi all, I am a middle aged male living in Georgia. I have been on seroquel for over ten years now for depression. There is no question it has helped my depression, but now I feel I am dependent on it. Whenever I try to come down on the dose (currently 400), I get horrible anxiety and panic attacks for weeks. The crazy thing is that even when I go back on the previous dose as soon as the flareup starts, the flareup still lasts for weeks. This has happened multiple times to me. Has anyone ever heard of this? My doctor just says that I am a lot more sensitive to it than most people.