Hello, @gnew92. I can offer you my two cents in reference to Xolair. Moderna boosted 10/25/21, trip to ER 11/04/21. Hives and dermatographia ever since. Began the journey on 4 doses of Allerga 180 mg per day. Currently down to one dose every other day of Zyrtec. I am schedule to receive my 4th dose of Xolair in three days. Reading the side effects definitely scared me. My quality of life was suffering. I reached out to my PCP, my PCP of 18 years, and she recommended I give Xolair a try. By dose 2, I noticed the itchiness decreased, about 15 days that month of my scalp not bothering me. Dose 3 increased the good days to 23 that month. I tried at this point to eliminate the Zyrtec. Nope. I had to take the Zyrtec daily until my system settled. Having the epi pen with me is something I have gotten used to. I plan to continue the Xolair through August (total of 7 doses). If a miracle happens and the hives and dermatographia disappear, I will definitely post the good news.