That is not uncommon. I hope people understand that there is NO safe vacation from Prolia. There is no 'going off of Prolia' without the bone-shedding loss triggered by having 'gained' from being on it in the first place unless one immediately takes a different osteoporosis drug. Amgen, the manufacturer of Prolia, refers to the second, segue drug as a "relay" drug. My endocrinologist starts people, who are going to stop taking Prolia on the relay drug before they quit Prolia to try to establish a kind of safety net.