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MGUS and quite high Free Kappa Light Chain and Kappa Lambda Ratio

Blood Cancers & Disorders | Last Active: Jan 4 3:42pm | Replies (213)
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@gingerw

@jart When I have had the 24-hour urine test, they are looking for protein levels, so i cannot speak to findings like you have in that test.

MGUS typically is a "watch and wait" situation. Yes, it may put you on edge, but there is not any positive if you are worrying all the time! In my case, my myeloma progressed rather rapidly from MGUS to Smoldering Myeloma, to mutiple myeloma, in the course of 2 years. That was highly unusual, from everything I have researched, and my comorbidities no doubt played a factor. The very big majority of people go for many years without any progression of MGUS, and that is why a 3 or 6 month re-check protocol is put in place.

I hope this eases your mind.
Ginger

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jart | @jart | May 15, 2022

Thank you, Ginger. I know MGUS can lay dormant for one’s whole life. What I’m wondering about is the connection to Free Kappa Light Chain which is now quite high, as is the Kappa/Lambda ratio. I’m interested in learning if the two are connected and, if so, how … and what does it mean? Smoldering MM or Active. He sees hematologist tomorrow so trying to become more informed in prep for the appt.

I’m sorry to hear your situation progressed so rapidly. Sounds like you have a very good attitude. You have my admiration.

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