My husband is an avid walker/biker too and he was never bored while in Rochester for our 4.5 month stay. The trail system is great along the Zumbro river, Bear Creek, walking through neighborhoods and parks.
It’s a medium sized city with so much geared to the Mayo community. Very easy access off the highway so there’s absolutely no big city-white knuckle driving.

As for being with you 24/7…well, in truth your husband will need to be tethered to you pretty closely, especially the first 2 weeks after your autologous transplant. In my own experience that first month for my allogenic transplant (not using my own cells) I wasn’t (and couldn’t be) on my own very much. But even then, if I was was feeling ok or napping, my husband felt confident in heading out for a good hour or so. Plus, as I’m sure you’ll be, we were linked with cell phones in case I needed him.
This isn’t a walk in the park for you, my dear, so he’s going to need to be a direct part of your transplant journey. This time will pass quickly and you’ll be back home soon enough.

I’m working on a post right now for transplant patients who need to be in Rochester for long term care. It includes lodging ideas, what to bring, how to plan. I’ll post it within the week and let you know. I think it will be very helpful to anyone facing longterm stays at Mayo.
Do you have any specific questions for me right now that I can address in my post??