I'm taking a supplement that in theory has the calcium (from algae)! Vitamin D3* and vitamin K2** in balance. It's the one recommended by the owner of an indy vitamin store who's been in business for nearly 50 years and seems to know the good manufacturers that have survived in the competitive vitamin industry.

I'm uncertain about how much boron to take but have to check the label as this vegetarian supplement has trace elements and minerals. So look forward to someone posting about the boron question.

I did recently add a supplement to increase the silica after reading a study (which I cited elsewhere on Mayo Connect) on the importance of orthosilicic acid for bone renewal and health.

*Vitamin D3 may play a role in cancer prevention. I cited and linked a study about that elsewhere on Mayo Connect.

**Vitamin K2 is thought to help steer calcium to bones or (some studies are suggesting, the science is as usual a work in progress) make it more bioavailable for the bone renewal process.

I have osteopenia and am not taking any osteoporosis drugs so am hoping that giving my body anything else that it might use to retain what I currently have will pay off.

There might be choices other than Prolia that would work. The osteoporosis board has several threads about drugs people have experience with. There are also people on this thread with a lot of knowledge about the panoply of med treatments in the market for osteoporosis. But whatever you consider, please double-check cautions, side effects and any protocol limitations. Since some drug choices can preclude other, later ones. It's almost as if one needs to pre-plan a possible decadesworth treatment plan so as to ensure best future meds. That may change in the future as well though.