Does H. Pylori lead to stomach cancer?

Dear Mayo Clinic Connect Members,

I regret to inform you that I do not have nor have I ever had an H. Pylori infection according to this negative H. Pylori IgG/IgA/IgM antibody blood test. I told everyone around me that I finally had a diagnosis until now. 😢

I tested negative for H. Pylori on biopsy by upper endoscopy procedure, 15-20 urea breath tests and 10-15 stool antigen tests over the past 6-9 months. For these reasons I’m giving up on an H. Pylori diagnosis and all of my doctors have dismissed it now, too.

However, my symptoms fit an H. Pylori infection, chronic gastritis/duodenitis were discovered on upper endoscopy and I respond well to H. Pylori treatment. This leads me to believe I have a different infection in my upper GI tract and it’s either bacterial or parasitic in nature. 🦠

I’m working with a new specialist now and I’d like your thoughts on an alternative diagnosis. What bacterial or parasitic infections in the upper GI tract are chronic and produce symptoms that mimic an H. Pylori infection??

Also, I'm struggling to locate an infectious disease physician who specializes in diagnosing and treating parasitic infections in the North Texas region. Can you recommend someone for me? If so, please forward me his/her contact information so I can schedule a new patient appointment right away.

Thanks for your feedback!! 🙏

Hello everyone, my daughter began suffering from very specific symptoms 3 years ago after a trip to Mexico. Nausea, vomiting, diarrhea, abdominal pain, weight loss, chronic/debilitating fatigue, spontaneous uticaria wheals (skin rash), chronic acne after 2 rounds of failed Accutane. After multiple doctor visits over 3 years, too many tests to list, so many blood vials drawn I am surprised she has any blood left. WE FINALLY HAVE A DIAGNOSIS!!!! The original endoscopy showed Eosinophilic esophagitis EOE of an unknown origin. Original biopsies were negative for H. Pylori. 2 years later they did a repeat endoscopy and her biopsy is positive for H. Pylori. I am praying she will improve over the next 2 weeks. Never give up, there is a diagnosis out there, you have to keep looking.

Hi @bkarateew I am so happy that your daughter was finally diagnosed correctly. You'll see I moved your post to a discussion where one of our members went through the same thing. We tend to group like posts together so the members can connect and bond over shared experiences.

Do the doctors have an explanation as to why it took so long to positively diagnose her?

No, the said the first biopsy was negative but didn’t have a reason why.

My H Pylori was cured using antibiotics. I also take pantaprazole for Chronic Gastritis and to keep the acid under control. I also had a bleeding ulcer repaired via endoscope. I eat a low acid diet all the time. No booze,soda, lot's of water. No aspirin or Ibuphrofen. Cut out any spicey foods. Good Luck!

Hello help me please . Am terribly suffering from chronic H/pylori for almost three years now. I have used a lot of medicines like Heligo kit which consist of clarithromycin cupses, tinidazole, and secnidazole three times, with no improvement. Then I used the mixture of tetracycline, secnidazole, and pantoprazole for two weeks with no improvement again. Doctors decided to do endoscopy and removed a tissue to check for the types/ species of h.pylori and among the twelve species checked ten were positive with no medicine response. Dr recommended me to use BISMUTH and RIFABUTIN, and continue using pantoprazole but unfortunately BISMUTH AND RIFABUTIN are not available in my country (TANZANIA) I'M ALSO SUFFERING FROM PEPTIC ULCERS AND GASTRITIS. Help me please.

Hello help me please . Am terribly suffering from chronic H/pylori for almost three years now. I have used a lot of medicines like Heligo kit which consist of clarithromycin cupses, tinidazole, and secnidazole three times, with no improvement. Then I used the mixture of tetracycline, secnidazole, and pantoprazole for two weeks with no improvement again. Doctors decided to do endoscopy and removed a tissue to check for the types/ species of h.pylori and among the twelve species checked ten were positive with no medicine response. Dr recommended me to use BISMUTH and RIFABUTIN, and continue using pantoprazole but unfortunately BISMUTH AND RIFABUTIN are not available in my country (TANZANIA) I'M ALSO SUFFERING FROM PEPTIC ULCERS AND GASTRITIS. Help me please.

I have been having bloating and gas in my stomach. My doctor had a Cat Scan performed, and said it showed no tumor or easily fixed condition. He said "the stomach wall shows atrophy and that is probably the reason for my bloating and stomach distension".. But, he offered no advice on what, if anything, I could do about that. Does anyone have any ideas?

This is a correction of my post on "stomach wall atrophy". The correction term is "abdominal wall atrophy".

Hello help me please . Am terribly suffering from chronic H/pylori for almost three years now. I have used a lot of medicines like Heligo kit which consist of clarithromycin cupses, tinidazole, and secnidazole three times, with no improvement. Then I used the mixture of tetracycline, secnidazole, and pantoprazole for two weeks with no improvement again. Doctors decided to do endoscopy and removed a tissue to check for the types/ species of h.pylori and among the twelve species checked ten were positive with no medicine response. Dr recommended me to use BISMUTH and RIFABUTIN, and continue using pantoprazole but unfortunately BISMUTH AND RIFABUTIN are not available in my country (TANZANIA) I'M ALSO SUFFERING FROM PEPTIC ULCERS AND GASTRITIS. Help me please.