GeneSight.com is genetic testing site I used, with my psychiatrist's involvement, to determine an effective anti-depressant for me. I've been on Desvenlafaxine (50 mg / day) for 2-3 years, and it is working better than the many others I have ever been on, which were all in the column on the report of being only a little or moderately effective. I've had three suicidal ideation episodes at 72, and my brother (age 84) has tried to commit suicide at least 25 times, according to his wife of over 50 years who almost divorced him because of it many years ago. Thus, my depression is severe, and GeneSight.com was literally life-saving for me. FYI.