@sylvia67 and @colleenyoung I'm sorry to have been so absent from the site. My silly computer keeps sending everything to junk mail and deleting it but I'm fighting back, ha ha. Sylvia67 - sorry to hear about your brother. Colleen probably asked me to reply because my husband was diagnosed with 'cancer of unknown primary' 6 years ago. It's a cancer they can't quite identify. My husband presented with a small tumor in his lung and one in a lymph node near his lung. They assumed lung cancer but after 4 biopsies it doesn't match a specific cancer. It's hard to have cancer but to have one where they don't quite know what it is, even harder. My husband's cancer has spread multiple times and is treated either with chemo or radiation. We also have tried immunotherapy (which oddly made him even sicker?). The radiation works where it can be applied to get rid of the spread of cancer. Right now and off and on he has no signs of cancer and then it comes back. It's very hard to not know what is going to happen and hard for the doctors to know what to do to stop or slow it down. So far we've been fairly lucky that the radiation works. They chose chemo based on an assumption of lung cancer and we don't know if it worked or the radiation or the immunotherapy as they were all used at same time. I do a lot of my own research with the blessing of our oncology team. I have found a couple of rare lung cancers that are similar to his experience and as the cancer acts and spreads we've eliminated upper GI cancer so far. All I can add is ....tell your brother to get a second opinion - just in case and pester the doctors with ideas and questions to keep them working on the cancer type. We're blessed in that my husband is still here after 6 years and they gave him 6 months. They've been truly difficult years for him and for me but he's still here and we're grateful.