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Restless legs syndrome (RLS) and mirtazapine

Depression & Anxiety | Last Active: Oct 25, 2023 | Replies (66)

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Thank you for your reply.
I am 66 and in a dark state of depression and anxiety after withdrawing from Paxil of 25 years. I never questioned it all these years and had a happy life with no side effects. Depression started to creep in a few years ago. My leg tingling and tremor intensified. Cancer surgery 1 1/2 years ago. Then my mind and my tremors were out of control. Added Wellbutrin 150 but didn’t help. Last April psych took me off Paxil too quickly (I found out about withdrawal later 😫) doubled the Wellbutrin and neuro added Primidone for essential tremor. Sooo many Med changes at once.
I have been off Paxil for 8 months and my mind is getting worse and worse. Was so hoping to not go back on an antidepressant. I can’t stop thinking obsessively about my symptoms. Too much research about psych meds. So many side effects. Have lost 50#, can’t sleep, ruminate, no joy. I had a happy, productive life and I want that back.
Cymbalta has also been recommended along with lexapro and remeron.
How has cymbalta helped you? And why are you on Wellbutrin with it?
My RL bothers me in bed mostly and has become noticeable in the past few months, I wonder if Wellbutrin had helped it. The tingling is 24/7. Saw an integrative doc and they want Me on tons of supplements. Being a traditional Med person all my life, these make me nervous. I just don’t know what to do but I can’t live like this.

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Replies to "Thank you for your reply. I am 66 and in a dark state of depression and..."

Rosa- It's just awful the way doctors think that your mind can bounce around so much with medication. I have felt somewhat like you. If I were you I'd go for a second opinion and get help with your anti-depressants. You don't need to live like this, nor should you. Paxil is a biggie for withdrawal symptoms, so take care. Depression is a big side effect of cancer.

My mindset is that I know that I need an antidepressant. And I'll live with it. It's all about my quality of life. When I got off of Effexor after taking it for years I knew that I needed help, that depression was part of my makeup. So that's why I thought that way.

One of the side effects of Cymbalta is sweating. And boy did I with a 90mg dose. I had taken Welbutrin for quite a while with sertraline so I just went back on that. We'll see how it works out. I have really liked Cymbalta and wished that I could tolerate the sweating. It helped me out of feeling like you do.

As far as RLS I did not like Primidone, or something similar. My tremors come on and off and I haven't figured out what is triggering it to act up. I love Ropinirole. My RLS is at night or very late in the afternoon. I hate, hate the feeling. I don't know what underlying conditions you have right now, other than cancer that might interfere with any of the drugs that you take or might try.

Where are you with cancer right now?