I have recently been prescribed Azithromyicin to be added back in to the Big 3. Originally I was taking Ethamathrol, Anikacin, Rifibutin and then Azithromyicin and Clofaximine were added. My liver enzymes rapidly elevated so I was taken off of everything. After a short time Ethamathrol and Clofaximine were started and last week Azithromyicin at half dosage (250 mg.) was added. Since adding the Azithromyicin my lab results look good; however I have woken up with a headache every day and it lasts all day long. I have tried taking the "Z" med at night and then mid day, with no difference in the headache. Any suggestions? Also how does one explain this diagnosis to one's friends? I look the same to them but can't do the things I used to do. This is a weird time in my life!!!