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Anyone else out there with extremely high lipoprotein (a)?

Heart & Blood Health | Last Active: Oct 16 1:38pm | Replies (173)
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@hopeful33250

Hi @whineboy,

I appreciate your pointing that out. I cited an incorrect link when I posted to you earlier today. I should have posted, https://www.atherosclerosis-journal.com/article/S0021-9150(19)31392-9/fulltext. This article states that in certain individuals it does increase the lipoprotein (a). It seems to be dependent on the apo phenotype.

The different studies certainly were confusing,

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Replies to "Hi @whineboy, I appreciate your pointing that out. I cited an incorrect link when I posted..."
whineboy | @whineboy | Mar 14, 2022

Hello Teresa,

I finally worked through that very technical article. I'm not sure if it is relevant to the general population, 85% of participants were caucasian, ~ 86% of the 81 participants had familial hypercholesterolimia, and ~ 19% were smokers. The authors noted the small size and observational nature of the study (not an RCT) were limiting. Yes, the study showed that for those with the LMW apo(a) phenotype, whatever that is 🙂 , statins increased Lp(a) significantly, but not for those with the HMW apo(a) phenotype. Interestingly, the paper did not identify the statins used or their dosages.

I was pleased to see the authors noted that reduced fat intake and shifting from dietary saturated fat to unsaturated fat was previously associated with increased Lp(a).

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