Welcome @timcryan, I'm sorry to hear you are having more neuropathy pain at night. I'm wondering if you might find this discussion helpful -- Neuropathy Pain at Night: What helps?: https://connect.mayoclinic.org/discussion/night-pain-2/

Is the pain mostly in your feet and legs?

Greetings @timcryan, and welcome to Connect. This is a group of patients and caregivers who help others with quality of life issues. I would absolutely call nighttime Neuropathy pain something that can impact your quality of life. It can also make you sleep-deprived. So let's have a look. First of all, how long have you had neuropathy? Have you been diagnosed? And has that diagnosis included a skin test biopsy?

I have had SFN small fiber neuropathy for a number of years. Mine is related to trauma accidents and surgeries over the last 50 years. Ever since trying medical cannabis for the pain and tingling and numbness of SFN, I have been able to sleep pretty well. I use a dropper of a CBD/THC tincture that I take before bedtime. Mine happens to be a 2:1 mixture of CBD and THC. Within about 20 minutes I wander off to sleep and wake up refreshed in the morning.

What have you tried? I am not good with opioids or OTC medications. My PCP is very supportive and together we evaluate and plan my daily routine. Because I succumb to anxiety quite easily I also use Duloxetine in the morning to take the edge off the anxiety that can create pain.

In addition to tinctures, I use a CBD:THC topical for both acute and chronic pain.

I am going to have to have some more information from you so that I can refine these suggestions to make them provide the greatest support.

Where on your body is the neuropathy pain the worst?
May you be free of suffering and the causes of suffering.
Chris