Well, this kind of answers my question. I wanted to know how long it would take to get out of my system. I HAD to come off of Anastrozole. I was hurting all over. It will not be 2 months until the middle of March. I could hardly function. I knew about side effects, and I rarely have them from medications, but this is/was terrible. After consulting my oncologist, she did say that some of her patients said it took a long time to finally feel better. She ordered Tamoxifen, which I have not started yet. I did not want to take that on top of Anastrozole. I will wait until I feel back to normal. In fact, I will wait until after my breast surgery to start another medication. That will be March 30th. Does anyone have any info regarding taking Tamoxifen? The only info from my gynecologist was that it is in the same family as Anastrozole, leading me to believe I still may have those side effects. The only thing I have heard is it will not be as bad.