Never use anything with preservatives in your eye, especially benzalkonium chloride (BAK), which is in nearly every eye lubricant. BAK disrupts and inflames your ocular surface. It's used to INDUCE dry eye in animal experimentation. Go to pubmed and search benzalkonium chloride and dry eye, if you find this hard to believe. Why do ophthalmologists and optometrists continue to prescribe BAK containing drops? I sure as heck can't figure it out. Because my insurance won't pay for BAK free glaucoma medication, my doctor has sent a prescription for Zioptan (preservative free) to Eagle Pharmacy in Florida, who ship it to me. I use Purilens as my daily lubricant. Another note: I tried silicone punctal plugs many years ago. Large gross looking tumor type things grew out of the inner corners of my eyes. My ophthalmologist said I must be allergic to silicone. So I had acrylic plugs inserted, and unfortunately chose a brand that was later recalled for causing frequent infections. My doc had a heck of time trying to get all of both plugs out of my eyes, and I refused subsequent plugs. Another note: if you have rosacea and/or blephartitis , try using Zocular wipes for cleansing. I cut the wipes into smaller squares for cleansing, because the wipes are expensive. Follow this up with Derma-Care smoothed lightly over the rims of your eyelids.