The main issue with Prolia seems to be that you can't get off meds after starting it. When you stop Prolia there is a relatively quick, steep drop in bone density, according to what I have read and what my doc says. Most only take Prolia for 5 years and then what do you take? Both Prolia and Reclast/Fosamax suppress bone turnover resulting in brittle bones over 5-10 years. So going on Reclast after Prolia doesn't seem great either. This scenario AFTER Prolia is the real problem with it. (Reclast stays in your system for a long time after you stop so doesn't have the quick drop off in bone density.) My endocrinologist will not put me on Prolia, ever.

As to side effects, those lists of side effects and negative comments can be scary but the company is legally required to disclose every possible side effect. All I can say is that I have a friend who was on it for 5 years with no side effects. Of course, people like her don't post!