I'm sure you are aware of the common concerns like bleeding; all blood thinners have them. Mine was an uncommon (rare but severe) side effect: muscle weakness in legs. Looking back, it began a few months after going on Eliquis; legs felt like they were "jelly". My Cardiologist kept me on it even after an Ablation that cured my Afib.

For more than 4 years I needed a wheelchair if I had to travel more than a few hundred yards.

My Chiropractor (of all people) made the connection. Neither my primary nor my Cardiologist had ever heard of that side effect.

With Cardiologists OK, went off Eliquis December 23, 2022 and a week later could walk the half mile to our mail station and back w/o a problem! Six weeks later, I'm walking 2-3 miles a day at a 2 - 2.5 miles an hour pace.