After taking for 8 days, I decided I needed to quit taking. It was affecting my appetite, which is not a good thing for me. I was just getting to where my appetite was getting better before starting on the Duloxetine. I’m trying to gain back some weight. Whatever the chemotherapy treatments did to me besides the neuropathy is affecting my abdomen area and my head, such as brain fog. I also have tinnitus and it seemed to be getting worse. I never had the pain in my feet and hands, just numbness. I didn’t notice any difference. Mainly needed to stop because of the loss of appetite. I just know what my oncologist said was that these things could take up to two years to disappear. From what I have read, maybe never. That is what is troubling!