I started statins in 1986 when my doctor detected cholesterol level of 380. Tried every statin and always got to level 2 pain. My current cardiologist was involved in the Repatha study and eventual prescribed it for me. Self injector, once every two weeks. After my first two months and a test by my cardiologist, I received a note from his nurse with a little heart sticker - cholesterol level below one hundred. Love it. I did talk to the cardiologist about my DPN and he researched the study findings and could not find any info re adverse effects. Just have to remember that DPN is a one in 300,000 disease - perhaps none had high cholesterol.