Hello All,

Your comments are very helpful and I'm glad to have found this forum. I hope that my story will help you as yours have encouraged me. My internal vibrations are more like buzzing and began 13 years ago inside my inner right calf. Initially they were intermittent and not very often. Now they are 24/7, and are in my entire body, including my lips, which is unnerving, no pun intended. 😉 I don't experience that "relaxed" feeling any more and many autonomic problems have developed including electrical conduction problems that involve my heart (Midodrine was a game changer!). I can feel the physical toll this condition has caused my body and anxiety was ruled out through tests. Because of the timing of the onset of my symptoms in correlation with the city in which I live, first using insecticides and pesticides to control the mosquito population, I think there is a connection between organophosphate poisoning and my internal buzzing and autonomic dysfunctions. Spending years trying to figure out why this is happening and trying to eliminate the buzzing and return to a peaceful relaxed state of body, I started using select amino acids and neurotranmitter supplements. A neurologist suggested that I eat 3 eggs a day and when I asked why, she stated that "I needed the choline". Since eating 3 eggs a day wasn't realistic for me, I began using the supplements I mentioned and my journey for relief continued. Recently I was tested for acetylcholine receptor dysfunction because of the "choline" recommendation and I noticed that a couple of the meds I've been using affect the muscarinic receptors which are part of the cholinergic receptors system. To learn more about this important system, I appreciated Osmosis.org's explaination of Cholinergic receptors. I think there is a correlation between the Cholinergic system and our vibrating/buzzing sensations. My acetylcholine receptor antibody tests were negative for dysfunction and my Movement Disorder Neurologist prescribed Baclofen. Low and behold, Baclofen reduced my buzzing/vibrations YEA, but it exacerbated my autonomic dysfunctions and I had to discontinue it. To date, I've received the most relief from using the supplements L-Tryptophan and pure California Poppy tincture. A word of caution, all supplements are not created equally and can impact health and medications, so please check with your doctor before trying them. In closing, I suspect that genetic mutations may be a component of this physical experience. Have any of you been tested for the genetic COMT mutation? Having the genetic COMT mutation can affect how the body utilizes certain meds that some of you in this forum have mentioned using. I'm interested in hearing from you and may you receive answers and relief!