@nimalw, Good morning. I will share my experience of what is the best time for me. When I say best time, it is the time that has worked well for my since my transplant in 2009. 8:00 AM and 8:00 PM with minimal adjustments as needed.
My transplant team said to select a time that I knew I could adhere to. I am not confined to eat with/without food because this has allowed me to consistently take my meds, and my levels are stable with a happy liver/kidney. I do, however, still take my bedtime meds like allergy, BP, at bedtime.

Do you take your meds with food? If decide to try an earlier dose, I suggest you make a gradual adjustment. Do you think an earlier dose might be possible for you?