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Post prostatectomy: What do rising PSA levels mean?

Prostate Cancer | Last Active: May 26 4:55pm | Replies (188)

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@dpybarra

I had a Radical Retro Pubic Prostatectomy August 2021
The PSA 3 months after was 0.01. I had a routine physical in December and the lab work showed the PSA now is 0.05 a 400% increase. I messaged the surgeon at Duke Cancer Center who will do another set of labs the first part of March. I was told that 0.05 is still considered undetectable. I am concerned with the sharp rise in just a month, Should I be concerned? I also had a Decipher genetic test, that said I was intermediate risk for a reoccurrence. The only thing on the test that I saw as a red flag was the positive result for Perineural invasion, meaning that cancer was detected in the nerves within the prostate. Can anyone shed any light or guidance on this?

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Replies to "I had a Radical Retro Pubic Prostatectomy August 2021 The PSA 3 months after was 0.01...."

Welcome @dpybarra, you'll notice that I moved your message to this existing discussion where @hoard was asking the same questions. I encourage you to read through the sage advice from fellow members
- Post prostatectomy: What do rising PSA levels mean? https://connect.mayoclinic.org/discussion/post-prostatectomy/

As you likely know, the PSA test alone is not enough to determine cause or next steps. Your doctor will likely order additional tests or followup in a few months with another PSA test. Do you have a followup appointment schedule with your oncologist?