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Erosive Osteoarthritis

Bones, Joints & Muscles | Last Active: Sep 6, 2023 | Replies (100)

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@johnbishop

Hi Elizabeth @ess77, I don't have much knowledge on Plaquenil but did find two articles that mention it's use in treating the conditions.

"As a treatment for sarcoidosis, the antimalarial drug hydroxychloroquine (Plaquenil®) is most ... Severe vasculitis can be associated with exudates that." -- SARCOIDOSIS TREATMENT GUIDELINES: https://www.stopsarcoidosis.org/wp-content/uploads/FSR-Physicians-Protocol1-1.pdf

"Antimalarials - Chloroquine and hydroxychloroquine have been frequently used in treatment of sarcoidosis based on early randomized trials that showed a long-term benefit with chloroquine (56). However, based on the better safety profile, hydroxychloroquine is most often preferred. The mechanisms of action for hydroxychloroquine are varied; it can interfere with antigen presentation, prevent T cell activation, inhibit toll-like receptor signaling, and reduce inflammatory cytokines by T cells and B cells (57). Hydroxychloroquine has been particularly useful in cutaneous disease, hypercalcemia, and in some cases of neurosarcoidosis (58–60). Although gastrointestinal side effects are commonly reported with use of hydroxychloroquine, they are generally mild and well-tolerated (61)." -- Treatment of Sarcoidosis: A Multidisciplinary Approach: https://www.frontiersin.org/articles/10.3389/fimmu.2020.545413/full

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Replies to "Hi Elizabeth @ess77, I don't have much knowledge on Plaquenil but did find two articles that..."

@johnbishop, Wow, John, a plethora of wonderful information. you've helped me ins so many different ways and this is a great help. I'm digging into research as this may be something to finally give me some help. Since I have digestive issues and heart issues as well, I need to ck and think clearly. I've had a gut feeling about this drug for a couple of years after first hearing about it and thought from the first it might help me with some of the things I have. So, thanks for your research and info. You are the greatest!
Any ideas about boron?
Blessings. elizabeth