← Return to Rare serious side effect of Eliquis: Muscle weakness

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@cmauncc1

I looked at the links you suggested, but didn't see anything relating muscle weakness to Eliquis.

I am, unfortunately, a naive patient. It never occurred to me or my wife that muscle weakness was a possible side effect of Eliquis as that isn't mentioned in the literature accompanying its initial Rx or any refills.

All I knew was that my legs were getting progressively weaker! No, we didn't connect that to my being on a new med! Yep, naive

Six weeks ago my Cardiologist dropped me to Eliquis 2.5mg 2x/day following a Watchman consult that declared me a marginal candidate for the procedure due to my only clot/stroke risk factor being my age (79). The ablation in late 2017 worked; less than 0.5% Afib since then.

I was only clued in ten days ago by my Chiropractor that he has seen several patients with my ongoing leg issues that began shortly after starting Eliquis. He printed off a sheet that indicates "Muscle weakness" is rare but "Serious" side effect.

It has now been four+ years since I was first put on 5mg Eliquis 2x/day, complaining frequently to my 2013-2020 primary and to my 2021++ primary [change due to insurance changing], and to my Cardiologist about my leg weakness. At 79 I am otherwise in very good condition (heart, BP, lungs, other organs, and labs within normal range), with the Afib under control.

At this point, quality of life (the HOPE of being able to improve my leg strength and my ability to walk better by eliminating Eliquis completely) outweighs the minimal risk of clot/stroke. [A verbose way of saying that "No, I have not consulted my Cardiologist!]

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Replies to "I looked at the links you suggested, but didn't see anything relating muscle weakness to Eliquis...."

Please................please..................once you start Eliquis, you cannot stop it. If you do, the one scary part is to be eligible for BRAIN HEMMORAGE. If taken off, must be substituted with another type, but your brain is trained to get to the source of pain. Don't cause a rumble in your head with this much advertised pill on TV. Dangerous product. Doctor's and Nurses do not tell you about the BH (above). They are either experimenting with you or just want to lessen your pain. Does not work that way. Find (mean this seriously, another Doctor). Flipping Doctor's is nothing to be ashamed of. We need to protect our health and become educated. Life is shorter without education. Judy G.

I am on eliqus as well. I had 2 clots within a year and a half. Never could find out what caused them but I was put on the eliquis, I have noticed some muscle weakness in my legs as well, not to the extent you seem to be experiencing but enough to get my attention. There are times my legs feel like they are gonna give out on me just waking up the stairs and I'm only 40, I work construction and work-out 4 to 6 days a week. It is something that is def a little concerning to me, I would like to know what it is that makes eliquis have that effect on the muscles

So glad people are posting abt leg weakness on Eliquis. This can explain mine. I am 74 have been kn eliquis for 8 years for paroxysmal afib. Two years ago i developed sudden weakness in lower extremities. Up til that point I had been participating in HIIT twice a week plus other aerobic activities when suddenly i couldn’t lift the ropes ( exercise equipment). Now again having very weak legs even though I am working out and strength training.