Hi @crabman, Have you considered stopping taking Areds 2 for a month or so to see if the muscle tightness, cramping goes away? Here's some information I found on the NIH National Eye Institute that may be helpful.

AREDS/AREDS2 Frequently Asked Questions: https://www.nei.nih.gov/research/clinical-trials/age-related-eye-disease-studies-aredsareds2/aredsareds2-frequently-asked-questions

I had the same thing. It is due to the excessive amount of Vitamin E in Areds -triple the required RDA amount - see the Mayo Clinic site for cautions about Vitamin E. If you are taking certain medications such as blood pressure & others it can cause reactions. You can take the other ingredients in Ared2 in separate vitamin pills, the zinc & copper combination & Lutein-zeaxanthin combination in another vitamin pill & probably enough vitamin E in a multivitamin. Talk to your pharmacist or licensed hospital dietitian.