I don't know anything about the Mayo Clinic but going to National Jewish will be well worth your trip. National Jewish also has great lab which can tell you exactly what bacteria you have any how many colonies you have. That is super important. I visited 1 year ago and spent a week there. They do a really good work up on you and then provide a treatment plan. I have NOT had to go on the Big Three. They are big on airway clearance and if you have GERD following the GERD rules.