Good morning @hello1234, Calcineurin inhibitors, Tacrolimus and Cyclosporine, can affect kidney function and raise creatinine levels, that’s one of the reasons that our levels are monitored. Mycophenolate, so far as my research has shown, doesn’t typically affect kidney function. However, that would be a question for your transplant team. It can definitely, however, as you know cause infections, which can certainly affect our kidneys.

As JK says, the best prevention to keep creatinine levels in normal ranges is to drink at least 80 ounces of water each day, at least for liver transplant recipients. I do this and my levels have always stayed around .55-.65 mg/ dL since my transplant. I take 6 mg Tac and 1,000 mg Mycophenolate each day.