Methotrexate comes in both pill form and liquid for injection. My present rheumatologist started me on pills but they weren't doing much yet and he increased my dose and then mentioned that it seems to work better when it's injected. I said that I could do that. I too am sorry that Arthritis Today quit being published. Anyway, the syringes I use are the tiny ones used for insulin and they don't hurt at all if you can grab a little roll of fat to poke.