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JAK2 Mutation - Effects and Questions
Blood Cancers & Disorders | Last Active: Jun 19 5:59am | Replies (303)Comment receiving replies
I met with new oncologist/hema this week. I will be getting a bone marrow biopsy, as expected, to determine the amount of fibrosis. Dr. was a bit optimistic that my CBC was not presenting evidence of MF. Other than a slightly elevated platelet count they are fairly stable and within margins each test. The enlarged spleen does not signify MF by itself. The JAK2 mutation is not hereditary, but the cause of it may be, not enough data on the subject to know what causes the mutation. It appears that this was caught early and potentially prior to the MPN presenting. Will know more after the biopsy. Be well.
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Hello Scott- My oncologist did the bone marrow procedure 3 years ago and confirmed the cause of high platelet count at 1.2 million. After SARS 2 vaccine, the platelet count went to 1.5 million and I began hydroxyurea 1000 mg per day which pulled the count down to .6 million. I continue to take hydroxyurea to reduce stroke risk from too many platelets. The side effects are brain fog, pale skin tone, ED, and a weird sense of being never experienced before for 74 years. I get a platelet count blood test monthly to monitor the level and continue a busy life of health care, family, volunteer work and business in that order. I hope that my experience helps you with the fear and uncertainty that come with an incurable disease. I look for studies and clinical trials to change and kill off the errant JAK2 cells/genes and create new JAK2 genes that are not cancerous. Stay tuned.
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I appreciate the report back, Scott. This all sounds promising, especially the part about your having got this early.