I believe my oncologist, a melanoma specialist, was only concerned with the melanoma and did not look at the potential for other cancers to be present or beginning to present. I had discussed with family changing oncologists, but felt it was important to see the melanoma treatment through. His theory, which is typical, is that JAK2 nor MF are hereditary and should not be a concern. May not have MF yet, but having enlarged spleen and JAK2 along with a few other symptoms.... Unfortunately, cures and full treatments are not in place for MF. The only "cure" is a replacement of bone marrow unless something else comes down the line.