Thank you so much for all information about the ibrance . I started on 125mg in March.I had my first breast cancer in 1996 went through chemo radiation and estrogen blockers . I’m 2014 breast cancer again had a double mastectomy no treatment. I’m 2021 had a T9 compression fracture In my spine and was diagnosed with stage 4 . It’s in a few bones . Tumor markers are way down. It’s sounds like you are doing really well on the ibrance . That’s always wonderful to hear..I also play golf snd walk but do get tired and have to rest a little more. Do you notice tiredness ?