Hi, I tried amitiza, trulance and linzess and nothing. PEG which is in miralax and many other laxatives in the same family makes me severely sick for days. Then in turn causes more weight loss, fatigue and an overall makes me miserable. I’m learning from so many that your body is just that, yours and what works for you won’t work for someone else. Fiber kills me almost always but we need it to poop. I get severe cramps. Water, I can drink half my body weight of water every day and nothing. Then I do much less and have a small BM. Stimulants make me hit the bathroom floor with massive pain,sweating and close to fainting. I think bowel problems for people who suffer severely comes with no rhyme or reason why this happens. I think we live with it most of our lives and we’re always trying to figure out why. I read here yesterday about pancreas and constipation. I had an mri for stomach and they found pancreatic cysts but I can’t get an appointment till January for follow up. My pcp ran test. I guess you just hope they are nothing. I mentioned the blog and reference to constipation and pancreas to my pcp. I suggested a simple lab test of amylase and lipace and his reply “I just don’t see the need”. It just baffles me if my insurance will cover, I have cysts so it can be justified he says no. They just can’t except we do our own research, well some doctors anyway. I feel I know my body well, I just wish doctors would listen to that. A pill is not always the right answer without at least some research. I’ll keep pushing along and hope I figure this out. Listening to everyone is uplifting and it helps. Someone just might mention something you never tried and it could work. All the best…Joanne