Hi Suzanne, well, I went to 4 of the Dr's in the Gastro group, all they did was suggest laxatives, I asked for tests and they said, wasn't necessary, I found Dr. Hsu in Princeton NJ, and he said "I will find out what's going on". He did a colonoscopy and endoscopy same time. Diagnosed with tortuous colon, sometimes referred as a long colon. Mine twists and turns, and said "no wonder you have constipation". Also, pancreatic insufficiency, only 50% of pancreas working, and a lot of inflammation. He put me Mesalamine for inflammation, etc.
Now, working with a certified nutritionist who specializes in digestive issues, IBS. etc.
Finally, after 10 years, some answers! it's all about keep trying, and finding the right Doctor.