I had only one shot! I started developing some side effects and decided to research . It’s a most controversial drug and the fact that once you start , it’s dangerous to ever stop! As I said that if I had known that from the beginning I NEVER would have taken it . So the only thing you can do to protect yourself coming off of Prolia is take a relay drug and the only relay drugs are bisphosphonates. ( I have a hiatal hernia and some reflux so that’s not helping me. ) I would stay on the bisphosphonates for x amount of time. However if I have a bad reaction I can stop immediately without the awful ramifications that Prolia can give you.