Hi @diane18 and welcome to Mayo Clinic Connect. I am sorry your husband is having side effects from Eliquis. You will see that I moved your post to a long ongoing conversation about Eliquis so that you can read and connect with other members who are on the same medication and have had questions about it.

Here is some reference information: "Jan 28, 2019 — But weight loss, another focus of the updated guidelines, is likely good for anyone with a-fib. The guidelines say losing weight can reduce ..." --- Cardiologist Groups Say Newer Blood Thinners Best Against A-Fib:
https://consumer.healthday.com/cardiovascular-health-information-20/atrial-fibrillation-959/cardiologist-groups-say-newer-blood-thinners-best-against-a-fib-741993.html

How long has he been on the medication and how dramatic was the weight loss?

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