Hi, my experience with anagrelide was unsuccessful, as I had severe reactions. I only used it for a few weeks. Sorry I can't be of more help. I have not had negative impacts with hydrea, so have continued with that for many years. I would not be worried about platelet counts up to 600,000. Many people seem to manage well with higher numbers that that. I, however, start to get pretty severe migraines if my counts rise over 500,000. Maybe you will do fine on anagrelide. Many people do.

I will have a cbc check in 1 month to see if the count is higher. Thank you for the advice. I guess my main concern is being on hydrea for so many years even though I do feel thankful for living somewhat of a normal life, and the only problem besides fatigue, joint pain, and in the last few years my gums have become difficult to keep healthy. It has been so helpful to have this site in order to read others experiences with this disorder. I have not had much support from my Dr. so thank you for all. the posts!