I'm a 72 yrs. old and I was diagnosed with ET in 2011 when my platelet count was 800,000. I was told by a Dr. that I probably had had it for 5+ years prior. After a bone marrow confirmation of ET with Jak2 positive I started on hydrea. I did have redness of my cornea and eye lid tissue, joint soreness, and bleeding gums especially when they dose was increased. My 1st oncologist told me it wasn't rare or a cancer which discouraged me when I was feeling several side effects with no support from her. My platelet count has had increased amounts several times during the duration of my disease. Increasing of the hydrea has maintained the platelet count from 350,000 - 500,000+. I take 11 500mgs a week. My most recent cbc indicated 600,000 platelet count. The oncologist is suspecting the hydrea may not be working, and wants to change meds to agrylin. Has anyone experienced the same issue and tried this medication.