Event the first couple of days on my new med dosing schedule - 2 carbidopa/levodopa pills four times per day (25-100); 3 1/2 hours apart - feel stronger already. Rytary did have a number of negative effects for me: overall physical tiredness, although I hadn't done serious exercises; thighs that could hardly hold me up on some days; more intense
anxiety/nervousness/irritableness; periodic but mild dyskinesia. My wife was watching me pretty carefully and jotted down most of the negative effects. So my neurologist/movement specialist gave me the usual test involving my ability to move and by the end of the teleconference, we had set up the new (traditional) med dosing schedule, noted above, and coupled with Azilect (rasageline, 1 mg per day). The extra dose of carbidopa./levodopa is included in the schedule to reduce off-periods. If the four-dose schedule doesn't work maximally, we will add a med like Orianze to better cover off-periods. Apparently, Stalevo is a "new" version of carb/lev EX, and carb / levo; and Rytary is a "new" version of carb / levo / entacapone. At any rate, Stalevo (brand name) and entacapone are used during off-periods of other meds (carb / levo) to treat "wearing off" of Parkinson's symtoms. Entacapone seems to be a strong med which helps during off-periods but might have serious negative effects. NOTE: Please share this message with the other PD patients on this collection of PD-related meds, dosing, negative drug effects, etc. [ Howard Scheiber PhD ]

Hi @parkiegirl,

Have you talked with your doctor about a replacement for the Rytary?
I hope that you begin to feel better.

Will you post an update when you start your new meds?