I tried every different medication out the from Gabapentins to Cymbalta etc & all of those affected me terribly where my head was in one spot & my body was halfway across the room somewhere or I was having terrible dreams & having fits of anger at people. The Gabapentin had me so off balance I fell & broke my hip. I then started out on Topiramate which helped with the electric shock feeling of neuropathy a bit but not near enough. I asked to try something else, anything so Savella came next, didn't seem to do much @ 25mg 2x a day so I experimented with 50mg 2x a day, spoke to my doc about further experimenting, it was okayed, so now I'm up to 300mg per day, 100mg 3x a day. This dose has helped allot in reducing the burning sensations, the electric shock sensations. They are still there tho, just not near as bad & some days it's still hard to get them to a tolerable level where I can comfortably stand or walk around & accomplish some household chores etc. Most days I've been just unable to do much or even leave my house cause of the pain & numbness, now I'm not having to 'force' myself to do things so much. It does nothing for the numbness tho. Hope this helps anyone considering Savella, that likely you need to reach the higher does levels in order to achieve any relief results, please keep trying it. I've not yet experienced any side effects. I feel I could go up more in doseage but will wait to meet with my neurologist or msg her before I do on my own.