I’ve done extensive research into herbs, supplements, etc. metabolized by the CYP3A pathways and which would therefore interact with Tacrolimus and Cyclosporine. I’ve only found one reference, attached, which does list oregano along with other “pungent spices,” if taken in large amounts.
But, if you really look at everything that is metabolized by CYP3A enzymes, we wouldn’t be enjoying most teas, coffee, soy, pepper, and a host of other things. Substances do vary in their interaction level due to strength, if they’re metabolized by both CYP3A4 & CYP3A5 (as with Tac and Cyclosporine), how much they’re processed by the liver, etc. So, since I was told coffee and tea is ok in moderation, I do have my half cup of coffee each morning!
I no longer take the oral oil of oregano tincture, as it’s, of course, concentrated. I do use 1 drop as a mouth wash to control oral thrush and the occasional skirt of SinuOrega nasal spray.
Happy travels JK!
@athenalee You have obviously researched this well. I was thinking it might be similar to Airborne and another OTC product that people use when flying to improve their immunity. Apparently SinuOrega is a very different product than those.
@loribmt It's really terrible that our country and families have become so divided on this issue. Fortunately all of our families have gotten vaccinated, and all of our close friends but I will no longer use the nail tech that I used to go to because she will not get vaccinated, nor will I use the house cleaner who I had every other week. Both of them were very good so I do miss them.
We will not socialize with non-vaccinated people, nor will eat inside of a restaurant, and even after having my third shot I am quite sure we will continue that. Frankly, we are old so at greater risk. People at any age can get a serious case and have long lingering effects but at my age and my husband's age, it could be a real problem.
JK