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New Study Reveals DANGER for immunocompromised.

Transplants | Last Active: Aug 27, 2021 | Replies (53)
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@contentandwell

Thanks, @athenalee for the encouraging words.

I have never heard of SinuOrega™ Nasal Spray before but are you sure that your transplant department is OK with it? I was told to not use the things like Airborne that people often use before flights because they do support your immune system, which of course is not what you want. Perhaps my transplant department is just ultra-conservative but I would definitely check with my transplant department before using it.

@rosemarya Your son's report back on flying is encouraging. My son said the same when he flew here but he is a bit more lax than I am.
JK

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Replies to "Thanks, @athenalee for the encouraging words. I have never heard of SinuOrega™ Nasal Spray before but..."
athenalee | @athenalee | Aug 23, 2021

I’ve done extensive research into herbs, supplements, etc. metabolized by the CYP3A pathways and which would therefore interact with Tacrolimus and Cyclosporine. I’ve only found one reference, attached, which does list oregano along with other “pungent spices,” if taken in large amounts.

But, if you really look at everything that is metabolized by CYP3A enzymes, we wouldn’t be enjoying most teas, coffee, soy, pepper, and a host of other things. Substances do vary in their interaction level due to strength, if they’re metabolized by both CYP3A4 & CYP3A5 (as with Tac and Cyclosporine), how much they’re processed by the liver, etc. So, since I was told coffee and tea is ok in moderation, I do have my half cup of coffee each morning!

I no longer take the oral oil of oregano tincture, as it’s, of course, concentrated. I do use 1 drop as a mouth wash to control oral thrush and the occasional skirt of SinuOrega nasal spray.

Happy travels JK!

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