I’m really happy to help in any way I can. My husband and I know what it’s like waiting for biopsy results. I’ve had so many over the past 2.5 years that it’s pretty routine now and we’re able to see the findings and know what they mean. Not sure if that’s a good or bad thing!

During the process of a bone marrow biopsy and exam (BMBX) a core sample of the bone marrow is taken along with an aspiration of some blood in the marrow as well. Both are studied in great detail with several tests run on each sample.

Knowing the specific mutations is important to the hematologist in planning the course of treatment, defining risk levels for relapse, how aggressive the disease is, etc..

So basically the answer to your question is yes. The reliable and standard practice to detect mutations in the blood are done with bone marrow biopsy.
Is this what you meant with your question?