@abrown2, you don't say whether you have had a good genetic analysis done, especially a whole genome sequencing. This is really the place to go next, I believe. And the prices have dropped dramatically in the last year or so. And you can actually start nearly free with Ambrygen.com or some others. If they can produce nothing that fits, you can move up to the 60-70 dollar range for a 1% sequencing. About the highest you can go now is about $600-800 for a whole genome sequencing at sequencing.com or Dante or others, with analysis. And most insurances will now cover the cost. Anytime the doc says he or she does not know, it is time for the genetics whizzes to go to work. And you don't need to travel to some center, at this point. I am an old man now, but at least I know what I have that is killing me slowly so I can save thousands I would waste on docs and meds and therapists. I have about 250,000 references in my 1% genome, and about 300 of them are pathogenic or likely, a bunch are risky, a few hundred trigger bad responses from medications such as statins, nsaids, etc. Many are just quiet, not doing any damage yet. And most are just quietly doing their good stuff, such as the ones that make me smarter than the average bear. At least that is what I tell my 17 great-grandchildren.