@hjscheib

I'm not sure about how different meds will react with Rytary. I've never taken Rytary. I did take Venlafaxene for a couple of years and it did not work well for me. However, I was taking a much smaller dose than you.

I switched several years ago to Cymbalta and feel much better. Cymbalta is good for sleeping as well as for pain. Talk with your doctor and see what he/she feels would be a good substitute for Venlafaxene.

If your doctor approves a change in meds, will you let me know how you are feeling?