I tried alternating Mirapex and REquip when one augmented and that worked for a while but since they are both the same class of med that doesn't work for me anymore. MIrapex works great for me until it augments and then I have to take what my neuro doc called a "drug holiday" when I really don't sleep at all. I take this holiday for at least 3 weeks (by then I'm a total wreck) and then can go back on the Pramipexole for 2-3 months until it all starts again. Have tried Neupro patch, carbadopa/levidopa, Lyrica, gabapentin but nothing works. I get a little sleep with oxycodone but have trouble getting it prescribed. RLS is ruining my life as I have to plan these "holidays" when nothing else is going on in my life - can't read, can't concentrate on preparing lectures, can't knit or even spend time with friends. As other people have said, I dread going to bed and having my legs jump!

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