@sandyrob , I went on Anastrozole after my diagnosis of breast cancer at age 62 as part of Mayo study. Was on for 6 months prior to surgery and had problems with depression and cognitive function. I did not have joint pain that many suffer from. I stayed on meds because a biopsy half way thru study showed it was reducing the tumor. I stopped taking when I had surgery and stayed off while on chemo and radiation. Surgery was lumpectomy and removal of two cancerous lymph nodes. I then tried two different AIs with similar side effects as Anastrozole. After a year I discussed with my oncologist and reviewed chance of recurrence. For me, due to type of cancer and treatment I had received, the difference in percent of reoccurrence with and without AI was minimal. So I stopped taking and feel so much better.

It has been 3 years since first diagnosis. I have recheck appointments with oncologist every 6 months and mammograms and MRI every year. MRI are due to dense breast.

When I went off AIs, the oncologist did a bone density test to compare pre cancer test to post treatment. Luckily my bone density had not changed. While on AIs, I was having infusion Zometa to help with bone health. Now that I am off AIs, no longer need.

Oncologist did tell me at last appt if imaging test show any changes we might have to discuss AIs again.

I have sister just diagnosed with breast cancer, her's was caught early and only had lumpectomy, no chemo or radiation. Her situation is different, and her chance of reoccurrence is much higher without AIs. She is having problems with side effects, but still taking.

It is VERY important to discuss with your oncologist your side effects and options.

Good luck
Laurie