I took one pill of Amitriptyline years ago and next day woke up to cotton mouth and felt really odd so didn't finish prescription, however, as with Wayne and many others, they can take it without adverse side effects. I did have my DNA checked against meds and under "Psychiatry" is listed for my DNA: AMITRIPTYLINE as having "Major gene-drug interaction"but this was after the above occurrence....... had the swab of cheek and sent away for the Oneome brand DNA test but was expensive; this was done after the above reaction. However, doctors don't have the time to look at my pages of test results so have realized a bit late that its up to me to take report with me to dr, especially if new dr or specialist, and show them and get their feedback. Best of luck, J.