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Transplant: Has anyone tapered off prednisone after decades of use?

Transplants | Last Active: Jul 16, 2021 | Replies (29)
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@tarmansbks

I hope someone has an answer. I have been on medrol for 14 years and would like to get off even though I know I will likely suffer pain in the joints. I understand the body depends on it for cortisol and can it make it on its own?

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Replies to "I hope someone has an answer. I have been on medrol for 14 years and would..."
Amanda Roe | @amandajro | Jul 10, 2021

Hello @tarmansbks and welcome to Mayo Clinic Connect. I believe you were asking if your body can produce cortisol on its own after tapering off your Rx. I found some information on that topic below that you might find of interest. Notably, the article does state the importance of a slow taper. "A gradual reduction in prednisone dosage gives your adrenal glands time to resume their normal function."

- Prednisone Withdrawal:
https://www.mayoclinic.org/prednisone-withdrawal/expert-answers/faq-20057923
Have you consulted with your doctor about this desire? Why are you interested in tapering?

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