The goal is to prevent the accumulation of fluid in the retina. The injections need to be administered on an ongoing basis to prevent the fluid accumulation. If your mother has a good retinal specialist, the injections should not hurt. They are mostly an inconvenience. The bigger concern is preventing fluid accumulation. The research indicates the injection protocol during the first few months is really important in protecting your mother's baseline vision. The research supports the benefits of frequent injections during the initial months. It seems your mother should be getting monthly injections especially given that she still has fluid. Are you near a medical school where the MDs may be more familiar with the latest research? Could you take your mother there and discuss more frequent injections?